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Dysregulated expression of IDO may cause unexplained recurrent spontaneous abortion through suppression of trophoblast cell proliferation and migration

27 Jan 2016

Abstract excerpt

In pregnancy, trophoblast proliferation, migration and invasion are important for the establishment and maintenance of a successful pregnancy. Impaired trophoblast function has been implicated in recurrent spontaneous abortion (RSA), a major complication of pregnancy, but the underlying mechanisms remain unclear. Indoleamine 2,3-dioxygenase (IDO), an enzyme that catabolizes tryptophan along the kynurenine...

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Share to Endometriosis Research and Treatment
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PMID: 26814137
DOI: 10.1038/srep19916

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Dysregulated expression of IDO may cause unexplained recurrent spontaneous abortion through suppression of trophoblast cell proliferation and migrationPMID 26814137Read ↗

Therapeutic targeting of the Tryptophan-Kynurenine Axis for HTR-8/SVneo trophoblast proliferation and migration in unexplained recurrent spontaneous abortionSemantic proximity Read ↗

The Role of the Placental Enzyme Indoleamine 2,3-Dioxygenase in Normal and Abnormal Human PregnancySemantic proximity Read ↗

Role of Indoleamine 2,3‐Dioxygenase and Tryptophan 2,3‐Dioxygenase in Patients with Recurrent MiscarriageSemantic proximity Read ↗

Dysregulation of MYBL2 impairs extravillous trophoblast lineage development and function, contributing to recurrent spontaneous abortionSemantic proximity Read ↗

miR-146b-5p downregulates IRAK1 and ADAM19 to suppress trophoblast proliferation, invasion, and migration in miscarriageSemantic proximity Read ↗

Upregulation of RND3 Affects Trophoblast Proliferation, Apoptosis, and Migration at the Maternal-Fetal InterfaceSemantic proximity Read ↗

Noncoding RNAs in Unexplained Recurrent Spontaneous Abortions and Their Diagnostic Potential.Semantic proximity Read ↗

<scp>LDHA</scp> deficiency inhibits trophoblast proliferation via the <scp>PI3K</scp> / <scp>AKT</scp> / <scp>FOXO1</scp> / <scp>CyclinD1</scp> signaling pathway in unexplained recurrent spontaneous abortionSemantic proximity Read ↗

The miR-410-5p /ITGA6 axis participates in the pathogenesis of recurrent abortion by regulating the biological function of trophoblastSemantic proximity Read ↗

MiR-103 protects from recurrent spontaneous abortion via inhibiting STAT1 mediated M1 macrophage polarizationSemantic proximity Read ↗

Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypesSemantic proximity Read ↗

IGFBP7 enhances trophoblast invasion via IGF-1R/c-Jun signaling in unexplained recurrent spontaneous abortionSemantic proximity Read ↗

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