Article
Immunology, genetics and microbiota in the COPD pathophysiology: potential scope for patient stratification.
Expert review of respiratory medicine - 1 Apr 2015
Malhotra Rajneesh, Olsson Henric
Abstract excerpt
Chronic obstructive pulmonary disease (COPD) is characterized by sustained inflammation of the airways, leading to destruction of lung tissue and declining pulmonary function. Although smoking is the most obvious risk factor for COPD, only about 20% of smokers develop COPD and smoking cessation d...
Topics
- Adaptive Immunity
- Epigenesis, Genetic
- Gene-Environment Interaction
- Genetic Predisposition to Disease
- Health Status
- Host-Pathogen Interactions
- Humans
- Immunity, Innate
- Lung
- Microbiota
- Phenotype
- Predictive Value of Tests
- Prognosis
- Pulmonary Disease, Chronic Obstructive
- Risk Factors
- Severity of Illness Index
- Smoking