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Article

How Does Multistep Tumorigenesis Really Proceed?

1 Jan 2015

Abstract excerpt

Identifying the cancer cells-of-origin is of great interest, as it holds the potential to elucidate biologic mechanisms inherent in the normal cell state that have been co-opted to drive the oncogenic cell state. An emerging concept, proposed here, states that cancer stem cells, key players in cancer initiation and metastasis, arise when transit-amplifying cells with mutant genomes dedifferentiate and enter the...

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PMID: 25583800
DOI: 10.1158/2159-8290.cd-14-0788

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