Article
Haptoglobin genotype and outcome after aneurysmal subarachnoid haemorrhage.
Journal of neurology, neurosurgery, and psychiatry - 1 Mar 2020
Morton Matthew J, Hostettler Isabel C, Kazmi Nabila, Alg Varinder S, Bonner Stephen, Brown Martin M, Durnford Andrew, Gaastra Benjamin, Garland Patrick, Grieve Joan, Kitchen Neil, Walsh Daniel, Zolnourian Ardalan, Houlden Henry, Gaunt Tom R, Bulters Diederik O, Werring David J, Galea Ian
Abstract excerpt
OBJECTIVE: After aneurysmal subarachnoid haemorrhage (aSAH), extracellular haemoglobin (Hb) in the subarachnoid space is bound by haptoglobin, neutralising Hb toxicity and helping its clearance. Two exons in the HP gene (encoding haptoglobin) exhibit copy number variation (CNV), giving rise to HP1 and HP2 alleles, which influence haptoglobin expression level and possibly haptoglobin function. We hypothesised that...
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