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Article

Transcriptional corepressor MTG16 regulates small intestinal crypt proliferation and crypt regeneration after radiation-induced injury.

American journal of physiology. Gastrointestinal and liver physiology - 15 Mar 2015

Poindexter Shenika V, Reddy Vishruth K, Mittal Mukul K, Williams Amanda M, Washington M Kay, Harris Elizabeth, Mah Amanda, Hiebert Scott W, Singh Kshipra, Chaturvedi Rupesh, Wilson Keith T, Lund P Kay, Williams Christopher S

Abstract excerpt

Myeloid translocation genes (MTGs) are transcriptional corepressors implicated in development, malignancy, differentiation, and stem cell function. While MTG16 loss renders mice sensitive to chemical colitis, the role of MTG16 in the small intestine is unknown. Histological examination revealed that Mtg16(-/-) mice have increased enterocyte proliferation and goblet cell deficiency. After exposure to radiation,...

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Identifiers

PMID: 25573176
DOI: 10.1152/ajpgi.00253.2014
PMCID: PMC4360050

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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