Article
Characterization of systemic metabolic phenotypes associated with subclinical atherosclerosis.
Molecular bioSystems - 1 Feb 2011
Würtz Peter, Soininen Pasi, Kangas Antti J, Mäkinen Ville-Petteri, Groop Per-Henrik, Savolainen Markku J, Juonala Markus, Viikari Jorma S, Kähönen Mika, Lehtimäki Terho, Raitakari Olli T, Ala-Korpela Mika
Abstract excerpt
Detailed molecular phenotyping gives insight into disease mechanisms and can individualize medical practice for improved risk assessment and treatment. We show in an epidemiological study (n = 4309) that the multi-metabolic profiles obtained by serum NMR metabonomics inherently associate with the extent of atherosclerosis already in preclinical stages. Data-driven analysis of the spectral profiles of healthy,...
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