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How I treat juvenile myelomonocytic leukemia

7 Jan 2015

Abstract excerpt

Juvenile myelomonocytic leukemia (JMML) is a unique, aggressive hematopoietic disorder of infancy/early childhood caused by excessive proliferation of cells of monocytic and granulocytic lineages. Approximately 90% of patients carry either somatic or germline mutations of PTPN-11, K-RAS, N-RAS, CBL, or NF1 in their leukemic cells. These genetic aberrations are largely mutually exclusive and activate the...

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PMID: 25564399
DOI: 10.1182/blood-2014-08-550483

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