Article
Increased prevalence of dhfr and dhps mutants at delivery in Malawian pregnant women receiving intermittent preventive treatment for malaria.
Tropical medicine & international health : TM & IH - 1 Feb 2013
Lin Jessica T, Mbewe Bernard, Taylor Steve M, Luntamo Mari, Meshnick Steven R, Ashorn Per
Abstract excerpt
In the context of an Intermittent preventive treatment (IPTp) trial for pregnant women in Malawi, Plasmodium falciparum samples from 85 women at enrollment and 35 women at delivery were genotyped for mutations associated with sulfadoxine-pyrimethamine resistance. The prevalence of the highly resistant haplotype with mutations at codons 51 and 108 of dihydrofolate reductase (dhfr) and codons 437 and 540 of...
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