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Article

Physical and methylation status of human papillomavirus 16 in asymptomatic cervical infections changes with malignant transformation

6 Jan 2015

Abstract excerpt

AIMS: To evaluate how the genetic and epigenetic profile of human papillomavirus 16 (HPV16) changes from asymptomatic cervical infections to cervical cancer (CaCx) development. METHODS: HPV16 physical status, methylation of its early-late promoters and its upstream enhancer sequences were analysed in samples from asymptomatic cervical infections (n=89), pre-neoplastic lesions (low and high grade squamous...

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PMID: 25563334
DOI: 10.1136/jclinpath-2014-202611

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