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Article

Analysis of an inactive cyanobactin biosynthetic gene cluster leads to discovery of new natural products from strains of the genus Microcystis.

PloS one - 1 Jan 2012

Leikoski Niina, Fewer David P, Jokela Jouni, Alakoski Pirita, Wahlsten Matti, Sivonen Kaarina

Abstract excerpt

Cyanobactins are cyclic peptides assembled through the cleavage and modification of short precursor proteins. An inactive cyanobactin gene cluster has been described from the genome Microcystis aeruginosa NIES843. Here we report the discovery of active counterparts in strains of the genus Microcystis guided by this silent cyanobactin gene cluster. The end products of the gene clusters were structurally diverse...

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Identifiers

PMID: 22952627
DOI: 10.1371/journal.pone.0043002
PMCID: PMC3428304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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