Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The cyanobacterial metabolite nocuolin a is a natural oxadiazine that triggers apoptosis in human cancer cells

2 Mar 2017

Abstract excerpt

Oxadiazines are heterocyclic compounds containing N-N-O or N-N-C-O system within a six membered ring. These structures have been up to now exclusively prepared via organic synthesis. Here, we report the discovery of a natural oxadiazine nocuolin A (NoA) that has a unique structure based on 1,2,3-oxadiazine. We have identified this compound in three independent cyanobacterial strains of genera Nostoc, Nodularia,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Marine Sponges and Natural Products
Share to Microbial Natural Products and Biosynthesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28253280
DOI: 10.1371/journal.pone.0172850

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The cyanobacterial metabolite nocuolin a is a natural oxadiazine that triggers apoptosis in human cancer cellsPMID 28253280Read ↗

Discovery, Synthesis, and Biological Evaluation of Anaenamides C and D from a New Marine Cyanobacterium, Hormoscilla sp.Semantic proximity Read ↗

Marine Cyanobacteria: A Source of Lead Compounds and their Clinically-Relevant Molecular TargetsSemantic proximity Read ↗

Suppression of IKK, but not activation of p53 is responsible for cell death mediated by naturally occurring oxidized tetranortriterpenoid.Semantic proximity Read ↗

Progress in the discovery and development of anticancer agents from marine cyanobacteriaSemantic proximity Read ↗

Uncovering the Bioactive Potential of a Cyanobacterial Natural Products Library Aided by Untargeted MetabolomicsSemantic proximity Read ↗

Viequeamide A, a Cytotoxic Member of the Kulolide Superfamily of Cyclic Depsipeptides from a Marine Button CyanobacteriumSemantic proximity Read ↗

Colombian cyanobacteria with cytotoxic activity in cancer cell linesSemantic proximity Read ↗

Damnacanthal is a potent inducer of apoptosis with anticancer activity by stimulating p53 and p21 genes in MCF-7 breast cancer cellsSemantic proximity Read ↗

Designing an Artificial Pathway for the Biosynthesis of a Novel Phenazine N-Oxide in Pseudomonas chlororaphis HT66Semantic proximity Read ↗

Antibacterial and Cytotoxic New Napyradiomycins from the Marine-Derived Streptomyces sp. SCSIO 10428Semantic proximity Read ↗

Halogenation‐Guided Chemical Screening Provides Insight into Tjipanazole Biosynthesis by the Cyanobacterium Fischerella ambiguaSemantic proximity Read ↗

Nyuzenamide C, an Antiangiogenic Epoxy Cinnamic Acid-Containing Bicyclic Peptide from a Riverine Streptomyces sp.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.