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Isolation, Structure Elucidation, and Total Synthesis of Tryptopeptins A and B, New TGF-β Signaling Modulators from Streptomyces sp.

5 Jan 2015

Abstract excerpt

Two new microbial metabolites, tryptopeptins A (1) and B (2), were isolated from the cultured broth of Streptomyces sp. KUSC-G11, as modulators of the transforming growth factor-β (TGF-β) signaling pathway. Their chemical structures consisting of isovalerate, N-Me-L-Val, L-allo-Thr, and a tryptophan-related residue were elucidated on the basis of spectroscopic analyses, while they were unambiguously determined by...

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PMID: 25560738
DOI: 10.1021/ol503340k

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