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Isoketals form cytotoxic phosphatidylethanolamine adducts in cells

26 Nov 2009

Abstract excerpt

Levuglandins and their stereo- and regio-isomers (termed isolevuglandins or isoketals) are gamma-ketoaldehydes (IsoK) that rapidly react with lysines to form stable protein adducts. IsoK protein adduct levels increase in several pathological conditions including cardiovascular disease. IsoKs can induce ion channel dysfunction and cell death, potentially by adducting to cellular proteins. However, IsoKs also...

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PMID: 19965577
DOI: 10.1194/jlr.m001040

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