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Article

The influence of the CHIEF pathway on colorectal cancer-specific mortality.

PloS one - 1 Jan 2014

Slattery Martha L, Lundgreen Abbie

Abstract excerpt

Many components of the CHIEF (Convergence of Hormones, Inflammation, and Energy Related Factors) pathway could influence survival given their involvement in cell growth, apoptosis, angiogenesis, and tumor invasion stimulation. We used ARTP (Adaptive Rank Truncation Product) to test if genes in the pathway were associated with colorectal cancer-specific mortality. Colon cancer (n = 1555) and rectal cancer (n =...

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Source

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Identifiers

PMID: 25541970
DOI: 10.1371/journal.pone.0116169
PMCID: PMC4277466

Genes

SMAD3
JAK2
DUSP2
MMP1
RAF1
RUNX3
TLR2
TYK2
VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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