Article
CD8 T cell tolerance to a tumor-associated self-antigen is reversed by CD4 T cells engineered to express the same T cell receptor.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2015
Ghorashian Sara, Veliça Pedro, Chua Ignatius, McNicol Anne-Marie, Carpenter Ben, Holler Angelika, Nicholson Emma, Ahmadi Maryam, Zech Mathias, Xue Shao-An, Uckert Wolfgang, Morris Emma, Chakraverty Ronjon, Stauss Hans J
Abstract excerpt
Ag receptors used for cancer immunotherapy are often directed against tumor-associated Ags also expressed in normal tissues. Targeting of such Ags can result in unwanted autoimmune attack of normal tissues or induction of tolerance in therapeutic T cells. We used a murine model to study the phenotype and function of T cells redirected against the murine double minute protein 2 (MDM2), a tumor-associated Ag that...
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