Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting Mycobacterium tuberculosis topoisomerase I by small-molecule inhibitors.

Antimicrobial agents and chemotherapy - 1 Mar 2015

Godbole Adwait Anand, Ahmed Wareed, Bhat Rajeshwari Subray, Bradley Erin K, Ekins Sean, Nagaraja Valakunja

Abstract excerpt

We describe inhibition of Mycobacterium tuberculosis topoisomerase I (MttopoI), an essential mycobacterial enzyme, by two related compounds, imipramine and norclomipramine, of which imipramine is clinically used as an antidepressant. These molecules showed growth inhibition of both Mycobacterium...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to DNA, Bacterial
Share to DNA Topoisomerases, Type I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mycobacterium smegmatis

Share to Mycobacterium tuberculosis

Share to Small Molecule Libraries

Share to Topoisomerase I Inhibitors

Share to Tuberculosis

Source

Open in PubMed Open full text

Identifiers

PMID: 25534741
DOI: 10.1128/AAC.04516-14
PMCID: PMC4325804

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25534741-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Targeting Mycobacterium tuberculosis topoisomerase I by small-molecule inhibitors.PMID 25534741Read ↗

DNA topoisomerase I and DNA gyrase as targets for TB therapySemantic proximity Read ↗

Conditional silencing of topoisomerase I gene of Mycobacterium tuberculosis validates its essentiality for cell survival.Semantic proximity Read ↗

Deciphering the distinct role for the metal coordination motif in the catalytic activity of Mycobacterium smegmatis topoisomerase I.Semantic proximity Read ↗

A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.Semantic proximity Read ↗

Type IA topoisomerase inhibition by clamp closure.Semantic proximity Read ↗

Novel N-linked aminopiperidine-based gyrase inhibitors with improved hERG and in vivo efficacy against Mycobacterium tuberculosis.Semantic proximity Read ↗

Predictive modeling targets thymidylate synthase ThyX in Mycobacterium tuberculosisSemantic proximity Read ↗

Doxorubicin inhibits E. coli division by interacting at a novel site in FtsZ.Semantic proximity Read ↗

Mutation adjacent to the active site tyrosine can enhance DNA cleavage and cell killing by the TOPRIM Gly to Ser mutant of bacterial topoisomerase I.Semantic proximity Read ↗

Inhibition of type IA topoisomerase by a monoclonal antibody through perturbation of DNA cleavage-religation equilibrium.Semantic proximity Read ↗

Inhibition of the human immunodeficiency virus type 1 integrase by guanosine quartet structures.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.