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Upregulation of CYP2S1 by oxaliplatin is associated with p53 status in colorectal cancer cell lines

9 Sept 2016

Abstract excerpt

Oxaliplatin displays a wide spectrum of antitumor activities and is widely used in the treatment of metastatic colorectal cancer (CRC). However, tumor responses to this agent are variable, and the underlying mechanisms are poorly understood. In the present study, oxaliplatin was found to strongly inhibit the growth of HCT116 cells harboring wild-type p53 but to only weakly inhibit SW480 cells, HT29 cells or...

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PMID: 27609465
DOI: 10.1038/srep33078

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