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Article

Jun-regulated genes promote interaction of diffuse large B-cell lymphoma with the microenvironment

23 Dec 2014

Abstract excerpt

Diffuse large B-cell lymphoma (DLBCL) is an aggressive disease with a high proliferation rate. However, the molecular and genetic features that drive the aggressive clinical behavior of DLBCL are not fully defined. Here, we have demonstrated that activated Jun signaling is a frequent event in DLBCL that promotes dissemination of malignant cells. Downregulation of Jun dramatically reduces lymphoma cell adhesion to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25533033
DOI: 10.1182/blood-2014-04-568188

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