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Article

Modulation of p53 and met expression by Krüppel-like factor 8 regulates zebrafish cerebellar development.

Developmental neurobiology - 1 Sept 2015

Tsai Ming-Yuan, Lu Yu-Fen, Liu Yu-Hsiu, Lien Huang-Wei, Huang Chang-Jen, Wu Jen-Leih, Hwang Sheng-Ping L

Abstract excerpt

Krüppel-like factor 8 (Klf8) is a zinc-finger transcription factor implicated in cell proliferation, and cancer cell survival and invasion; however, little is known about its role in normal embryonic development. Here, we show that Klf8 is required for normal cerebellar development in zebrafish embryos. Morpholino knockdown of klf8 resulted in abnormal cerebellar primordium morphology and the induction of p53 in...

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PMID: 25528982
DOI: 10.1002/dneu.22258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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