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Correlating Minimum Inhibitory Concentrations of ofloxacin and moxifloxacin with gyrA mutations using the genotype MTBDRsl assay.

Tuberculosis (Edinburgh, Scotland) - 1 Mar 2015

Kambli Priti, Ajbani Kanchan, Sadani Meeta, Nikam Chaitali, Shetty Anjali, Udwadia Zarir, Rodwell Timothy C, Catanzaro Antonino, Rodrigues Camilla

Abstract excerpt

OBJECTIVE: To correlate gyrA mutations found on the Genotype MTBDRsl assay in Mycobacterium tuberculosis (MTB) isolates with Minimum Inhibitory Concentrations (MICs) to the fluoroquinolones compounds ofloxacin (OFX) and moxifloxacin (MXF). METHODS: MICs for OFX and MXF were ascertained for 93 archived clinical MTB isolates that showed gyrA mutations at Ala90Val, Ser91Pro, Asp94Ala, Asn/Tyr, Gly and His. Thirty...

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Identifiers

PMID: 25522842
DOI: 10.1016/j.tube.2014.11.003
PMCID: PMC4361297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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