Article
Level of macroautophagy drives senescent keratinocytes into cell death or neoplastic evasion
18 Dec 2014
Abstract excerpt
Senescence is a non-proliferative state reached by normal cells in response to various stresses, including telomere uncapping, oxidative stress or oncogene activation. In previous reports, we have highlighted that senescent human epidermal keratinocytes have two opposite outcomes: either they die by autophagic programmed cell death or they evade in the form of neoplastic postsenescence emergent (PSNE) cells....
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