Article
Single nucleotide polymorphism markers for low-dose aspirin-associated peptic ulcer and ulcer bleeding.
Journal of gastroenterology and hepatology - 1 Dec 2014
Shiotani Akiko, Murao Takahisa, Fujita Yoshihiko, Fujimura Yoshinori, Sakakibara Takashi, Nishio Kazuto, Haruma Ken
Abstract excerpt
BACKGROUND AND AIM: In our previous study, the SLCO1B1 521TT genotype and the SLCO1B1*1b haplotype were significantly associated with the risk of peptic ulcer in patients taking low-dose aspirin (LDA). The aim of the present study was to investigate pharmacogenomic profile of LDA-induced peptic ulcer and ulcer bleeding. METHODS: Patients taking 100 mg of enteric-coated aspirin for cardiovascular diseases and with...
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