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Article

Assessment of cancer cell line representativeness using microarrays for Merkel cell carcinoma.

The Journal of investigative dermatology - 1 Apr 2015

Daily Kenneth, Coxon Amy, Williams Jonathan S, Lee Chyi-Chia R, Coit Daniel G, Busam Klaus J, Brownell Isaac

Abstract excerpt

When using cell lines to study cancer, phenotypic similarity to the original tumor is paramount. Yet, little has been done to characterize how closely Merkel cell carcinoma (MCC) cell lines model native tumors. To determine their similarity to MCC tumor samples, we characterized MCC cell lines via gene expression microarrays. Using whole transcriptome gene expression signatures and a computational bioinformatic...

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Source

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Identifiers

PMID: 25521454
DOI: 10.1038/jid.2014.518
PMCID: PMC4366303

Genes

MCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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