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Article

[Clinical aspects of hereditary spastic paraplegias].

Rinsho shinkeigaku = Clinical neurology - 1 Jan 2014

Shimazaki Haruo

Abstract excerpt

Hereditary spastic paraplegias (HSPs) were characterized by progressive leg spasticity with various additional symptoms as follows: peripheral neuropathy, cerebellar ataxia, extrapyramidal symptoms, mental impairment, optic atrophy, pigmental retinopathy, and so on. Many genetic loci (SPG1-72) and more than 50 genes were identified so far. Recently, we identified the causative gene, C12orf65, that was reported...

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Source

Identifiers

PMID: 25519961
DOI: 10.5692/clinicalneurol.54.1012

Genes

LYST
SPG11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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