[Hereditary spastic paraplegia: up to date].

Abstract excerpt

Hereditary spastic paraplegia (HSP) is a clinically and genetically heterogeneous group of neurodegenerative disorders that are clinically characterized by progressive spasticity and weakness of the lower limbs. HSP genetic loci are designated SPG1-72 in order of their discovery. In 206 Japanese families with autosomal dominant HSP, SPG4 was the most common form, accounting for 38%, followed by SPG3A (5%), SPG31...

Topics

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• Japan
• Mitochondrial Proteins
• Mutation
• Paraplegia
• Peptide Termination Factors
• Phenotype