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Mechanistic, Functional, and Clinical Aspects of Pro‐inflammatory Cytokine Mediated Regulation of ADME Gene Expression in 3D Human Liver Spheroids

12 Jun 2023

Abstract excerpt

During systemic inflammation, pro-inflammatory cytokines alter metabolism and transport of drugs affecting the clinical outcome. We used an in vivo like human 3D liver spheroid model to study the effects and mechanisms of pro-inflammatory cytokines on the expression of 9 different genes encoding enzymes responsible for the metabolism of > 90% of clinically used drugs. Treatment of spheroids with...

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PMID: 37307233
DOI: 10.1002/cpt.2969

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