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Article

Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders.

Nature communications - 18 Dec 2014

Aiyar Raeka S, Bohnert Maria, Duvezin-Caubet Stéphane, Voisset Cécile, Gagneur Julien, Fritsch Emilie S, Couplan Elodie, von der Malsburg Karina, Funaya Charlotta, Soubigou Flavie, Courtin Florence, Suresh Sundari, Kucharczyk Roza, Evrard Justine, Antony Claude, St Onge Robert P, Blondel Marc, di Rago Jean-Paul, van der Laan Martin, Steinmetz Lars M

Abstract excerpt

Mitochondrial diseases are systemic, prevalent and often fatal; yet treatments remain scarce. Identifying molecular intervention points that can be therapeutically targeted remains a major challenge, which we confronted via a screening assay we developed. Using yeast models of mitochondrial ATP s...

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Identifiers

PMID: 25519239
DOI: 10.1038/ncomms6585
PMCID: PMC4284804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25519239-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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