Article
ADH1B and ADH1C genotype, alcohol consumption and biomarkers of liver function: findings from a Mendelian randomization study in 58,313 European origin Danes.
PloS one - 1 Jan 2014
Lawlor Debbie A, Benn Marianne, Zuccolo Luisa, De Silva N Maneka G, Tybjaerg-Hansen Anne, Smith George Davey, Nordestgaard Børge G
Abstract excerpt
BACKGROUND: The effect of alcohol consumption on liver function is difficult to determine because of reporting bias and potential residual confounding. Our aim was to determine this effect using genetic variants to proxy for the unbiased effect of alcohol. METHODS: We used variants in ADH1B and ADH1C genes as instrumental variables (IV) to estimate the causal effect of long-term alcohol consumption on alanine...
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