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Article

Serum endostatin is a genetically determined predictor of survival in pulmonary arterial hypertension.

American journal of respiratory and critical care medicine - 15 Jan 2015

Damico Rachel, Kolb Todd M, Valera Lidenys, Wang Lan, Housten Traci, Tedford Ryan J, Kass David A, Rafaels Nicholas, Gao Li, Barnes Kathleen C, Benza Raymond L, Rand James L, Hamid Rizwan, Loyd James E, Robbins Ivan M, Hemnes Anna R, Chung Wendy K, Austin Eric D, Drummond M Bradley, Mathai Stephen C, Hassoun Paul M

Abstract excerpt

RATIONALE: Pulmonary arterial hypertension (PAH) is a medically incurable disease resulting in death from right ventricular (RV) failure. Both pulmonary vascular and RV remodeling are linked to dynamic changes in the microvasculature. Therefore, we hypothesized that circulating angiostatic factors could be linked to outcomes and represent novel biomarkers of disease severity in PAH. OBJECTIVES: We sought to...

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Identifiers

PMID: 25489667
DOI: 10.1164/rccm.201409-1742OC
PMCID: PMC4347439

Genes

PAH

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