Toward the development of effective transmission-blocking vaccines for malaria

Abstract excerpt

The continued global burden of malaria can in part be attributed to a complex lifecycle, with both human hosts and mosquito vectors serving as transmission reservoirs. In preclinical models of vaccine-induced immunity, antibodies to parasite sexual-stage antigens, ingested in the mosquito blood meal, can inhibit parasite survival in the insect midgut as judged by ex vivo functional studies such as the membrane...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Invertebrate Immune Response Mechanisms
• Share to Malaria Research and Control
• Share to Mosquito-borne diseases and control