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Global Phylogenomic Analysis of NonencapsulatedStreptococcus pneumoniaeReveals a Deep-Branching Classic Lineage That Is Distinct from Multiple Sporadic Lineages

1 Dec 2014

Abstract excerpt

The surrounding capsule of Streptococcus pneumoniae has been identified as a major virulence factor and is targeted by pneumococcal conjugate vaccines (PCV). However, nonencapsulated S. pneumoniae (non-Ec-Sp) have also been isolated globally, mainly in carriage studies. It is unknown if non-Ec-Sp evolve sporadically, if they have high antibiotic nonsusceptiblity rates and a unique, specific gene content. Here,...

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PMID: 25480686
DOI: 10.1093/gbe/evu263

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