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The invasive GAS puzzle in Italy: genomic insights from a hospital cohort in a fragmented surveillance landscape.

Frontiers in cellular and infection microbiology - 1 Jan 2025

Rosato Roberto, Santarelli Giulia, Fiori Barbara, Monzo Francesca Romana, Cafaro Giordana, D'Inzeo Tiziana, La Sorda Marilena, Creti Roberta, Posteraro Brunella, Sanguinetti Maurizio, De Maio Flavio

Abstract excerpt

Streptococcus pyogenes (Group A Streptococcus, GAS) is a re-emerging human pathogen responsible for a wide spectrum of diseases, from mild pharyngitis to life-threatening invasive infections that have risen globally in recent years. We performed a retrospective genomic and epidemiological analysis of 61 invasive Group A Streptococcus (iGAS) isolates collected from 2016 to 2024 at a major tertiary Italian...

Topics

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Antigens, Bacterial
Bacterial Outer Membrane Proteins
Genome, Bacterial
Interspersed Repetitive Sequences

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Streptococcal Infections

Streptococcus pyogenes

Virulence Factors

Whole Genome Sequencing

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Open in PubMed Open full text

Identifiers

PMID: 41574303
DOI: 10.3389/fcimb.2025.1684665
PMCID: PMC12819700

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