Emergence of multidrug-resistant ST876 serotype 14 Streptococcus pneumoniae with spontaneous mutations driving pathogenesis: genomic and clinical insights from pneumococcal pericarditis and global screening.

Abstract excerpt

Background: Streptococcus pneumoniae pericarditis is rare and lethal, yet how the pathogen evolves within the host during blood-to-pericardium spread remains unknown. Methods: Two ST876 serotype 14 strains, hz23B (blood) and hz23P (pericardial effusion), were isolated from one purulent pericarditis patient. We determined antimicrobial susceptibility test (AST) by broth microdilution, performed whole-genome...

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