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Article

Evaluation of clonal origin of malignant mesothelioma.

Journal of translational medicine - 4 Dec 2014

Comertpay Sabahattin, Pastorino Sandra, Tanji Mika, Mezzapelle Rosanna, Strianese Oriana, Napolitano Andrea, Baumann Francine, Weigel Tracey, Friedberg Joseph, Sugarbaker Paul, Krausz Thomas, Wang Ena, Powers Amy, Gaudino Giovanni, Kanodia Shreya, Pass Harvey I, Parsons Barbara L, Yang Haining, Carbone Michele

Abstract excerpt

BACKGROUND: The hypothesis that most cancers are of monoclonal origin is often accepted as a fact in the scientific community. This dogma arose decades ago, primarily from the study of hematopoietic malignancies and sarcomas, which originate as monoclonal tumors. The possible clonal origin of malignant mesothelioma (MM) has not been investigated. Asbestos inhalation induces a chronic inflammatory response at...

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Identifiers

PMID: 25471750
DOI: 10.1186/s12967-014-0301-3
PMCID: PMC4255423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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