Article
Genetics of immune-mediated disorders: from genome-wide association to molecular mechanism.
Current opinion in immunology - 1 Dec 2014
Kumar Vinod, Wijmenga Cisca, Xavier Ramnik J
Abstract excerpt
Genetic association studies have identified not only hundreds of susceptibility loci to immune-mediated diseases but also pinpointed causal amino-acid variants of HLA genes that contribute to many autoimmune reactions. Majority of non-HLA genetic variants are located within non-coding regulatory region. Expression QTL studies have shown that these variants affect disease mainly by regulating gene expression. We...
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