Article
Influence of component 5a receptor 1 (C5AR1) -1330T/G polymorphism on nonsedating H1-antihistamines therapy in Chinese patients with chronic spontaneous urticaria.
Journal of dermatological science - 1 Dec 2014
Yan Siyu, Chen Wangqing, Wen Shu, Zhu Wu, Guo Aiyuan, Chen Xiaoping, Zhang Chong, Chen Mingliang, Zhang Jianglin, Su Juan, Zhao Yue, He Yijing, Liu Zhaoqian, Zhou Honghao, Zeng Weiqi, Li Jie, Chen Xiang
Abstract excerpt
BACKGROUND: The nonsedating H1-antihistamines are the first-line medicines for chronic spontaneous urticaria (CSU) patients. However, not all these patients respond well to the antihistamines, and the mechanisms underlying the interindividual differences are still unclear. C5AR1 gene encodes the component 5a receptor (C5aR) protein, which has been reported to play an important role in chronic spontaneous...
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