Article
ε2 allele and ε2-involved genotypes (ε2/ε2, ε2/ε3, and ε2/ε4) may confer the association of APOE genetic polymorphism with risks of nephropathy in type 2 diabetes: a meta-analysis.
Lipids in health and disease - 13 Jun 2020
Shi Jikang, Cheng Zhaorui, Qiu Shuang, Cui Heran, Gu Yulu, Zhao Qian, Ren Yaxuan, Zhang He, Sun Helin, Liu Yunkai, Li Yong, Qiao Yichun, Hu Yueyang, Liu Yawen, Cheng Yi
Abstract excerpt
BACKGROUND: Diabetic nephropathy (DN) contributes to end-stage renal failure. Microvascular injury resulted from reactive oxygen species is implicated in the pathogenesis of DN. Genetic polymorphism of Apolipoprotein E (APOE) influences the antioxidative properties of the protein. The relationship of APOE polymorphism with the risks of nephropathy in type 2 diabetes (T2DN) remains elusive. METHODS: An up-to-date...
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