Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glial dysfunction causes age-related memory impairment in Drosophila.

Neuron - 19 Nov 2014

Yamazaki Daisuke, Horiuchi Junjiro, Ueno Kohei, Ueno Taro, Saeki Shinjiro, Matsuno Motomi, Naganos Shintaro, Miyashita Tomoyuki, Hirano Yukinori, Nishikawa Hiroyuki, Taoka Masato, Yamauchi Yoshio, Isobe Toshiaki, Honda Yoshiko, Kodama Tohru, Masuda Tomoko, Saitoe Minoru

Abstract excerpt

Several aging phenotypes, including age-related memory impairment (AMI), are thought to be caused by cumulative oxidative damage. In Drosophila, age-related impairments in 1 hr memory can be suppressed by reducing activity of protein kinase A (PKA). However, the mechanism for this effect has been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Animals, Genetically Modified

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Conditioning, Classical

Share to Cyclic AMP-Dependent Protein Kinases

Share to Drosophila

Share to Memory

Share to Memory Disorders

Share to Neuroglia

Source

Identifiers

PMID: 25447741
DOI: 10.1016/j.neuron.2014.09.039

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25447741-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glial dysfunction causes age-related memory impairment in Drosophila.PMID 25447741Read ↗

Recent insights into the role of glia and oxidative stress in Alzheimer's disease gained from DrosophilaSemantic proximity Read ↗

[cAMP/PKA signaling underlies age-related memory impairment].Semantic proximity Read ↗

The Drosophila DCO mutation suppresses age-related memory impairment without affecting lifespan.Semantic proximity Read ↗

Mitochondrial aconitase 1 regulates age‐related memory impairment via autophagy/mitophagy‐mediated neural plasticity in middle‐aged fliesSemantic proximity Read ↗

Age-dependent memory loss, synaptic pathology and altered brain plasticity in the Drosophila mutant cardinal accumulating 3-hydroxykynurenine.Semantic proximity Read ↗

Drosophila as a novel animal model for studying the genetics of age-related memory impairment.Semantic proximity Read ↗

Drosophila alicorn is a neuronal maintenance factor protecting against activity-induced retinal degeneration.Semantic proximity Read ↗

d-Aspartate oxidase influences glutamatergic system homeostasis in mammalian brain.Semantic proximity Read ↗

Glial β-oxidation regulates Drosophila energy metabolism.Semantic proximity Read ↗

Effects of D-amino acids on sleep in Drosophila.Semantic proximity Read ↗

Serine metabolism in the brain regulates starvation-induced sleep suppression in Drosophila melanogaster.Semantic proximity Read ↗

Deficiency in protein L-isoaspartyl methyltransferase results in a fatal progressive epilepsy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.