Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Otx1 promotes basal dendritic growth and regulates intrinsic electrophysiological and synaptic properties of layer V pyramidal neurons in mouse motor cortex.

Neuroscience - 29 Jan 2015

Zhang Y-F, Liu L-X, Cao H-T, Ou L, Qu J, Wang Y, Chen J-G

Abstract excerpt

The transcription factor Otx1 is specifically expressed in layer V pyramidal cells (L5PCs) in the cerebral cortex. Otx1 null mutant mice have a defect in the developmental axon pruning of L5PCs and show epileptic seizures. However, the role of Otx1 in electrophysiology, morphology and synaptology of the cortical neurons has not been fully investigated. This study examines the influences of Otx1 on neuronal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dendrites
Share to Electric Stimulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electroporation

Share to Excitatory Postsynaptic Potentials

Share to Motor Cortex

Share to Otx Transcription Factors

Share to Pyramidal Cells

Share to Tissue Culture Techniques

Source

Identifiers

PMID: 25446351
DOI: 10.1016/j.neuroscience.2014.11.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Otx1 promotes basal dendritic growth and regulates intrinsic electrophysiological and synaptic properties of layer V pyramidal neurons in mouse motor cortex.PMID 25446351Read ↗

Roles of glutamate receptor delta 2 subunit (GluRdelta 2) and metabotropic glutamate receptor subtype 1 (mGluR1) in climbing fiber synapse elimination during postnatal cerebellar development.Semantic proximity Read ↗

Mutations of CNTNAP1 led to defects in neuronal development.Semantic proximity Read ↗

Cerebellar zonal patterning relies on Purkinje cell neurotransmission.Semantic proximity Read ↗

Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.Semantic proximity Read ↗

Motor cortex layer V pyramidal neurons exhibit dendritic regression, spine loss, and increased synaptic excitation in the presymptomatic hSOD1(G93A) mouse model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Otud7a Knockout Mice Recapitulate Many Neurological Features of 15q13.3 Microdeletion Syndrome.Semantic proximity Read ↗

Aberrant axon initial segment is an indicator for task-independent neural activity in autism model miceSemantic proximity Read ↗

Loss of Piccolo function in rats induces Pontocerebellar Hypoplasia type 3-like phenotypesSemantic proximity Read ↗

Postnatal loss of P/Q-type channels confined to rhombic-lip-derived neurons alters synaptic transmission at the parallel fiber to purkinje cell synapse and replicates genomic Cacna1a mutation phenotype of ataxia and seizures in mice.Semantic proximity Read ↗

Loss of Piccolo Function in Rats Induces Cerebellar Network Dysfunction and Pontocerebellar Hypoplasia Type 3-like Phenotypes.Semantic proximity Read ↗

Signature morpho-electric, transcriptomic, and dendritic properties of extratelencephalic-projecting human layer 5 neocortical pyramidal neuronsSemantic proximity Read ↗

Axon initial segment structural plasticity in animal models of genetic and acquired epilepsy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.