Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interleukin-12B+1188A/C polymorphism contributes to increased hepatocellular carcinoma susceptibility: evidence from a meta-analysis.

Clinics and research in hepatology and gastroenterology - 1 Dec 2014

Peng Qiliu, Li Shan, Lao Xianjun, Chen Zhiping, Li Ruolin, Qin Xue

Abstract excerpt

BACKGROUND: Interleukin-12 (IL-12) is a multifunctional cytokine that induces interferon (IFN)-γ secretion and plays an important role in antitumor immunity. The IL-12B +1188A/C polymorphism was found to correlate with a decreased cytokine production and/or activity, which may lead to increased susceptibility to cancers including hepatocellular carcinoma (HCC). Previous epidemiological studies investigating the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukin-12 Subunit p40

Share to Liver Neoplasms

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 25445750
DOI: 10.1016/j.clinre.2014.09.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interleukin-12B+1188A/C polymorphism contributes to increased hepatocellular carcinoma susceptibility: evidence from a meta-analysis.PMID 25445750Read ↗

Meta-analysis of the association between the IL-12B +1188 A/C polymorphism and cancer risk.Semantic proximity Read ↗

Associations between hepatocellular carcinoma risk and rs3212227 and rs568408 polymorphisms: a systematic review and meta-analysis.Semantic proximity Read ↗

Interferon-γ +874A/T polymorphism and hepatocellular carcinoma risk: a meta-analysis.Semantic proximity Read ↗

Association of IL-6 polymorphisms with hepatocellular carcinoma risk: evidences from a meta-analysis.Semantic proximity Read ↗

Association between the Interleukin-10 -1082 G/A polymorphism and risk of hepatocellular carcinoma.Semantic proximity Read ↗

Association between interleukin-12 +1188A/C polymorphism and the risk of tuberculosis: A meta-analysis.Semantic proximity Read ↗

[Association between interleukin-18 gene polymorphisms and hepatocellular carcinoma caused by hepatitis B virus].Semantic proximity Read ↗

IL12 polymorphisms, HBV infection and risk of hepatocellular carcinoma in a high-risk Chinese population.Semantic proximity Read ↗

Alleles and genotypes of polymorphisms of IL-18, TNF-α and IFN-γ are associated with a higher risk and severity of hepatocellular carcinoma (HCC) in Brazil.Semantic proximity Read ↗

IL12 Gene Polymorphism in Association with Hepatocellular Carcinoma in HCV-infected Egyptian Patients.Semantic proximity Read ↗

The TNF-α, IL-1B and IL-10 polymorphisms and risk for hepatocellular carcinoma: a meta-analysis.Semantic proximity Read ↗

Functional polymorphisms in the interleukin-12 gene contribute to cancer risk: evidence from a meta-analysis of 18 case-control studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.