Interleukin-12B+1188A/C polymorphism contributes to increased hepatocellular carcinoma susceptibility: evidence from a meta-analysis.

doi:10.1016/j.clinre.2014.09.002

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Article

Interleukin-12B+1188A/C polymorphism contributes to increased hepatocellular carcinoma susceptibility: evidence from a meta-analysis.

Clinics and research in hepatology and gastroenterology - 1 Dec 2014

Peng Qiliu, Li Shan, Lao Xianjun, Chen Zhiping, Li Ruolin, Qin Xue

Abstract excerpt

BACKGROUND: Interleukin-12 (IL-12) is a multifunctional cytokine that induces interferon (IFN)-γ secretion and plays an important role in antitumor immunity. The IL-12B +1188A/C polymorphism was found to correlate with a decreased cytokine production and/or activity, which may lead to increased susceptibility to cancers including hepatocellular carcinoma (HCC). Previous epidemiological studies investigating the...

Topics

Carcinoma, Hepatocellular
Genetic Predisposition to Disease
Humans
Interleukin-12 Subunit p40
Liver Neoplasms
Polymorphism, Single Nucleotide

Source

Open in PubMed

Identifiers

PMID: 25445750
DOI: 10.1016/j.clinre.2014.09.002

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