Article
Genetic variations of IL17F and IL23A show associations with Behçet's disease and Vogt-Koyanagi-Harada syndrome.
Ophthalmology - 1 Mar 2015
Hou Shengping, Liao Dan, Zhang Jun, Fang Jing, Chen Lu, Qi Jian, Zhang Qi, Liu Yunjia, Bai Lin, Zhou Yan, Kijlstra Aize, Yang Peizeng
Abstract excerpt
PURPOSE: To investigate the associations of IL17A, IL17F, IL23A, and IL23R copy number variants (CNVs) with Vogt-Koyanagi-Harada (VKH) syndrome and Behçet's disease (BD) and the possible mechanisms involved. DESIGN: Two-stage case-control and functional studies. PARTICIPANTS: A total of 1159 VKH patients, 1036 BD patients, and 2050 controls were enrolled. METHODS: TaqMan real-time polymerase chain reaction assay...
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