Article
Molecular pathways of neurodegeneration in Parkinson's disease.
Science (New York, N.Y.) - 31 Oct 2003
Dawson Ted M, Dawson Valina L
Abstract excerpt
Parkinson's disease (PD) is a complex disorder with many different causes, yet they may intersect in common pathways, raising the possibility that neuroprotective agents may have broad applicability in the treatment of PD. Current evidence suggests that mitochondrial complex I inhibition may be the central cause of sporadic PD and that derangements in complex I cause alpha-synuclein aggregation, which contributes...
Topics
- Animals
- Animals, Genetically Modified
- Brain
- Cysteine Endopeptidases
- Dopamine
- Electron Transport Complex I
- Humans
- Mitochondria
- Multienzyme Complexes
- Mutation
- Nerve Degeneration
- Nerve Tissue Proteins