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Article

Are polymorphisms of the immunoregulatory factor CD40LG implicated in acute transfusion reactions?

Scientific reports - 28 Nov 2014

Aloui Chaker, Sut Caroline, Prigent Antoine, Fagan Jocelyne, Cognasse Fabrice, Granados-Herbepin Viviana, Touraine Renaud, Pozzetto Bruno, Aouni Mahjoub, Fendri Chedlia, Hassine Mohsen, Chakroun Tahar, Jemni-Yacoub Saloua, Garraud Olivier, Laradi Sandrine

Abstract excerpt

The CD40 ligand (CD40L/CD154), a member of TNF superfamily, is notably expressed on activated CD4+ T-cells and stimulated platelets. CD40L is linked to a variety of pathologies and to acute transfusion reactions (ATR). Mutations in this gene (CD40LG) lead to X-linked hyper-IgM syndrome. Some CD40LG polymorphisms are associated with variable protein expression. The rationale behind this study is that CD40L protein...

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Source

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Identifiers

PMID: 25430087
DOI: 10.1038/srep07239
PMCID: PMC5384113

Genes

ATR
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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