Article

In Silico Analysis and Modeling of Novel Pathogenic Single Nucleotide Polymorphisms (SNPs) in Human <i>CD40LG</i> Gene

2019-02-17

Abstract excerpt

<h4>Abstract:</h4> <h4>Background:</h4> The X-linked hyper-immunoglobulin M syndrome (XHIGM) is a rare, inherited immune deficiency disorder. It is more common in males. Characterized by elevated serum IgM levels and low to undetectable levels of serum IgG, IgA and IgE. Hyper-IgM syndrome is caused by mutations in the CD40LG gene. Located in human Xq26. CD40LG acts as an immune modulator in activated T cells....

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Literature Corpus work: 43dfdb87-bba2-5213-bda6-00cd05413482
DOI: 10.1101/552596

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