Article
[Pharmacogenetic algorithms for predicting the appropriate dose of vitamin K antagonists: are they still useful?].
Giornale italiano di cardiologia (2006) - 1 Oct 2014
Mundi Santa, Distante Alessandro, De Caterina Raffaele
Abstract excerpt
The severity of side effects that may occur with vitamin K antagonists due to their narrow therapeutic window requires great attention in finding out the most appropriate dose for these drugs. Pharmacogenetic research has now considerably helped clarifying the relationships between genetic variants and sensitivity to such therapy, paving the ground to predictive algorithms that include clinical and genetic...
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