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A Regulatory Feedback Loop between RpoS and SpoT Supports the Survival of Legionella pneumophila in Water

22 Nov 2014

Abstract excerpt

Legionella pneumophila is a waterborne pathogen, and survival in the aquatic environment is central to its transmission to humans. Therefore, identifying genes required for its survival in water could help prevent Legionnaires' disease outbreaks. In the present study, we investigate the role of the sigma factor RpoS in promoting survival in water, where L. pneumophila experiences severe nutrient deprivation. The...

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PMID: 25416763
DOI: 10.1128/aem.03132-14

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