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Loss of Wwox Perturbs Neuronal Migration and Impairs Early Cortical Development

11 Jun 2020

Abstract excerpt

Mutations in the WWOX gene cause a broad range of ultra-rare neurodevelopmental and brain degenerative disorders, associated with a high likelihood of premature death in animal models as well as in humans. The encoded Wwox protein is a WW domain-containing oxidoreductase that participates in crucial biological processes including tumour suppression, cell growth/differentiation and regulation of steroid...

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Identifiers

PMID: 32581702
DOI: 10.3389/fnins.2020.00644

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