Article
Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk.
Science (New York, N.Y.) - 30 Mar 2018
Zhang De-Liang, Wu Jian, Shah Binal N, Greutélaers Katja C, Ghosh Manik C, Ollivierre Hayden, Su Xin-Zhuan, Thuma Philip E, Bedu-Addo George, Mockenhaupt Frank P, Gordeuk Victor R, Rouault Tracey A
Abstract excerpt
Malaria parasites invade red blood cells (RBCs), consume copious amounts of hemoglobin, and severely disrupt iron regulation in humans. Anemia often accompanies malaria disease; however, iron supplementation therapy inexplicably exacerbates malarial infections. Here we found that the iron exporter ferroportin (FPN) was highly abundant in RBCs, and iron supplementation suppressed its activity. Conditional deletion...
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