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Article

Mild iron deficiency does not ameliorate the phenotype of a murine erythropoietic protoporphyria model.

American journal of hematology - 1 May 2020

Schmidt Paul J, Hollowell Monica L, Fitzgerald Kevin, Butler James S, Fleming Mark D

Abstract excerpt

Reduced ferrochelatase activity in erythropoietic protoporphyria (EPP) causes the accumulation of protoporphyrin IX (PPIX) leading to acute cutaneous photosensitivity and liver injury. Many EPP patients also have a mild hypochromic, microcytic anemia and iron deficiency. Iron deficiency can lead to decreased PPIX accumulation in another erythropoietic porphyria, congenital erythropoietic porphyria (CEP)....

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PMID: 31990410
DOI: 10.1002/ajh.25743

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