Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Telomere attrition and candidate gene mutations preceding monosomy 7 in aplastic anemia

19 Nov 2014

Abstract excerpt

The pathophysiology of severe aplastic anemia (SAA) is immune-mediated destruction of hematopoietic stem and progenitor cells (HSPCs). Most patients respond to immunosuppressive therapies, but a minority transform to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), frequently associated with monosomy 7 (-7). Thirteen SAA patients were analyzed for acquired mutations in myeloid cells at the time of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Hematopoietic Stem Cell Transplantation
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25406353
DOI: 10.1182/blood-2014-10-607572

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Telomere attrition and candidate gene mutations preceding monosomy 7 in aplastic anemiaPMID 25406353Read ↗

Perturbed hematopoietic stem and progenitor cell hierarchy in myelodysplastic syndromes patients with monosomy 7 as the sole cytogenetic abnormality.Semantic proximity Read ↗

Clonal evolution in inherited marrow failure syndromes predicts disease progression.Semantic proximity Read ↗

Monosomal karyotype predicts poor survival after allogeneic stem cell transplantation in chromosome 7 abnormal myelodysplastic syndrome and secondary acute myeloid leukemiaSemantic proximity Read ↗

The impact of concomitant cytogenetic abnormalities on acute myeloid leukemia with monosomy 7 or deletion 7q after HLA‐matched allogeneic stem cell transplantationSemantic proximity Read ↗

Clonal Evolution in Aplastic AnemiaSemantic proximity Read ↗

The enigma of monosomy 7Semantic proximity Read ↗

Distinct clinical outcomes for cytogenetic abnormalities evolving from aplastic anemiaSemantic proximity Read ↗

Mutational Landscape and Gene Expression Patterns in Adult Acute Myeloid Leukemias with Monosomy 7 as a Sole AbnormalitySemantic proximity Read ↗

Myelodysplastic syndrome, juvenile myelomonocytic leukemia, and acute myeloid leukemia associated with complete or partial monosomy 7. European Working Group on MDS in Childhood (EWOG-MDS).Semantic proximity Read ↗

Spontaneous remission and loss of monosomy 7: a window of opportunity for young children with SAMD9L syndromeSemantic proximity Read ↗

Impact of somatic mutations in myelodysplastic patients with isolated partial or total loss of chromosome 7.Semantic proximity Read ↗

Telomere shortening and chromosomal instability in myelodysplastic syndromesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.